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disruptive-gene-editing

  • Challenge:Future Innovator Prize
  • Phase:Seed
  • Team Lead:Prof. Wenxin Wang, University College Dublin
  • Team Co-Lead:Dr Nan Zhang, University College Dublin
  • Societal Impact Champion:Dr Sinead Hickey, Head of Research of DEBRA Ireland
disruptive-gene-editing

  • The Challenge

    Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare genetic skin fragility and blistering disorder in which no curative treatment currently exists with palliative care only in use.

  • The Solution

    Our proposed solution is to develop a gene editing curative treatment that can be applied topically to wound sites of RDEB patients.

    This therapeutic approach will enable the permanent correction of the underlying mutations that give rise to RDEB, in a non-invasive manner.